Autonomic and Cardiac Repolarization Lability in Long QT Syndrome Patients.

ABSTRACT:

Objective

Long QT-Syndrome (LQTS) patients are at risk of arrhythmias and seizures. We investigated whether autonomic and cardiac repolarization measures differed based on LQTS genotypes, and in LQTS patients with vs. without arrhythmias and seizures.

Methods

We used 24-h ECGs from LQTS1 (n = 87), LQTS2 (n = 50), and LQTS genotype negative patients (LQTS^(-), n = 16). Patients were stratified by LQTS genotype, and arrhythmias/seizures. Heart rate variability (HRV) and QT variability index (QTVI) measures were compared between groups during specific physiological states (minimum, middle, & maximum sympathovagal balance, LF/HF). Results were further tested using logistic regression for each ECG measure, and all HRV measures in a single multivariate model.

Results<

SUBMITTER: DeMaria N 

PROVIDER: S-EPMC7704776 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature