Detection of Immunotherapeutic Response in a Transgenic Mouse Model of Pancreatic Ductal Adenocarcinoma Using Multiparametric MRI Radiomics: A Preliminary Investigation.

ABSTRACT:

Rationale and objectives

To develop classification and regression models interpreting tumor characteristics obtained from structural (T1w and T2w) magnetic resonance imaging (MRI) data for early detection of dendritic cell (DC) vaccine treatment effects and prediction of long-term outcomes for LSL-Kras^G12D; LSL-Trp53^R172H; Pdx-1-Cre (KPC) transgenic mice model of pancreatic ductal adenocarcinoma.

Materials and methods

Eight mice were treated with DC vaccine for 3 weeks while eight KPC mice were used as untreated control subjects. The reproducibility of the computed 264 features was evaluated using the intraclass correlation coefficient. Key variables were determined using a three-step feature selection approach. Support vector machines classifiers were

SUBMITTER: Eresen A 

PROVIDER: S-EPMC7704817 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature