Early Mitochondrial Fragmentation and Dysfunction in a Drosophila Model for Alzheimer's Disease.

ABSTRACT: Many different cellular systems and molecular processes become compromised in Alzheimer's disease (AD) including proteostasis, autophagy, inflammatory responses, synapse and neuronal circuitry, and mitochondrial function. We focused in this study on mitochondrial dysfunction owing to the toxic neuronal environment produced by expression of Aβ42, and its relationship to other pathologies found in AD including increased neuronal apoptosis, plaque deposition, and memory impairment. Using super-resolution microscopy, we have assayed mitochondrial status in the three distinct neuronal compartments (somatic, dendritic, axonal) of mushroom body neurons of Drosophila expressing Aβ42. The mushroom body neurons comprise a major center for olfactory memory formation in insects. We employed calcium im

SUBMITTER: Wang X 

PROVIDER: S-EPMC7704861 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature