Whole-Exome Profiling of NSCLC Among African Americans.

ABSTRACT:

Introduction

Lung cancer incidence is higher among African Americans (AAs) compared with European Americans (EAs) in the United States, especially among men. Although significant progress has been made profiling the genomic makeup of lung cancer in EAs, AAs continue to be underrepresented. Our objective was to chart the genome-wide landscape of somatic mutations in lung cancer tumors from AAs.

Methods

In this study, we used the whole-exome sequencing of 82 tumor and noninvolved tissue pairs from AAs. Patients were selected from an ongoing case-control study conducted by the National Cancer Institute and the University of Maryland.

Results

Among all samples, we identified 178 significantly mutated genes (p < 0.05), five of which passed the threshold for false discovery

SUBMITTER: Arauz RF 

PROVIDER: S-EPMC7704928 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature