Intracellular Photophysics of an Osmium Complex bearing an Oligothiophene Extended Ligand.

ABSTRACT: This contribution describes the excited-state properties of an Osmium-complex when taken up into human cells. The complex 1 [Os(bpy)₂ (IP-4T)](PF₆ )₂ with bpy=2,2'-bipyridine and IP-4T=2-{5'-[3',4'-diethyl-(2,2'-bithien-5-yl)]-3,4-diethyl-2,2'-bithiophene}imidazo[4,5-f][1,10]phenanthroline) can be discussed as a candidate for photodynamic therapy in the biological red/NIR window. The complex is taken up by MCF7 cells and localizes rather homogeneously within in the cytoplasm. To detail the sub-ns photophysics of 1, comparative transient absorption measurements were carried out in different solvents to derive a model of the photoinduced processes. Key to rationalize the excited-state relaxation is a long-lived ³ ILCT state associated with the olig

SUBMITTER: Schneider KRA 

PROVIDER: S-EPMC7704931 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature