Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis.

ABSTRACT:

Background

Ketamine appears to have a therapeutic role in certain mental disorders, most notably depression. However, the comparative performance of different formulations of ketamine is less clear.

Objectives

This study aimed to assess the comparative efficacy and tolerability of racemic and esketamine for the treatment of unipolar and bipolar major depression.

Design

Systematic review and meta-analysis.

Data sources

We searched PubMed, MEDLINE, Embase, PsycINFO, the Cochrane Central Register of Controlled Clinical Trials, and the Cochrane Database of Systematic Reviews for relevant studies published since database inception and December 17, 2019.

Study eligibility criteria

We considered randomized controlled trials examining racemic or esketamine for t

SUBMITTER: Bahji A 

PROVIDER: S-EPMC7704936 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature