Ontology highlight
ABSTRACT:
SUBMITTER: Sun J
PROVIDER: S-EPMC7705194 | biostudies-literature | 2020 Jan-Dec
REPOSITORIES: biostudies-literature
Sun Jing J Yu Xijiao X Xue Lande L Li Shu S Li Jianxia J Tong Dongdong D Du Yi Y
Technology in cancer research & treatment 20200101
TP53 mutations are the most occurred mutation in HNSCC which might affect the ion channel genes. We aim to investigate the ion channel gene alteration under TP53 mutation and their prognostic implication. The overall mutation status of HNSCC were explored. By screening the TP53-associated ion channel genes (TICGs), an ion channel prognostic signature (ICPS) was established through a series of machine learning algorithms. The ICPS was then evaluated and its clinical significance was explored. 82 ...[more]