Cytokines and their relationship with the severity and prognosis of coronavirus disease 2019 (COVID-19): a retrospective cohort study.

ABSTRACT:

Objective

To delineate the characteristics and clinical significance of plasma inflammatory cytokines altered in COVID-19.

Design

Retrospective, single-centre cohort study.

Setting

Tongji Hospital in Wuhan, China.

Participants

Among a cohort of 308 patients with a diagnosis of COVID-19, 138 patients died while 170 patients recovered and were discharged from the hospital. The data were collected until 27 February 2020.

Primary and secondary outcome measures

Clinical characteristics and laboratory findings were obtained from electronic medical records using data collection forms.

Results

The percentage of patients with elevated interleukin 2 receptor (IL-2R), IL-6, IL-8, IL-10 and tumour necrosis factor (TNF) increased with severity of disease (p<0.

SUBMITTER: Liu QQ 

PROVIDER: S-EPMC7705426 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature