Test-retest repeatability of [¹⁸F]Flortaucipir PET in Alzheimer's disease and cognitively normal individuals.

ABSTRACT: The aim of this study was to investigate the test-retest (TRT) repeatability of various parametric quantification methods for [¹⁸F]Flortaucipir positron emission tomography (PET). We included eight subjects with dementia or mild cognitive impairment due to Alzheimer's disease and six cognitively normal subjects. All underwent two 130-min dynamic [¹⁸F]Flortaucipir PET scans within 3 ± 1 weeks. Data were analyzed using reference region models receptor parametric mapping (RPM), simplified reference tissue method 2 (SRTM2) and reference logan (RLogan), as well as standardized uptake value ratios (SUVr, time intervals 40-60, 80-100 and 110-130 min post-injection) with cerebellar gray matter as reference region. We obtained distribution volume ratio or SUVr, first for all b

SUBMITTER: Timmers T 

PROVIDER: S-EPMC7705644 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature