Macrophage-derived small extracellular vesicles promote biomimetic mineralized collagen-mediated endogenous bone regeneration.

ABSTRACT: Macrophages play an important role in material-related immune responses and bone formation, but the functionality of macrophage-derived extracellular vesicles (EVs) in material-mediated bone regeneration is still unclear. Here, we evaluated intracellular communication through small extracellular vesicles (sEVs) and its effects on endogenous bone regeneration mediated by biomimetic intrafibrillarly mineralized collagen (IMC). After implantation in the bone defect area, IMC generated more neobone and recruited more mesenchymal stem cells (MSCs) than did extrafibrillarly mineralized collagen (EMC). More CD63⁺CD90⁺ and CD63⁺CD163⁺ cells were detected in the defect area in the IMC group than in the EMC group. To determine the functional roles of sEVs,

SUBMITTER: Liu A 

PROVIDER: S-EPMC7705747 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature