Genetic and histopathological analysis of transverse testicular ectopia without persistent Mullerian duct syndrome: two case reports.

ABSTRACT:

Background

Transverse testicular ectopia (TTE) is a rare anomaly in which both testes descend through a single inguinal canal into the same hemiscrotum. Although almost 20-50% of patients with TTE exhibit persistent Müllerian duct syndrome (PMDS) and many genetic analyses have been performed, no reports have described the genes contributing to TTE without PMDS. Here, we report two cases of TTE without PMDS using immunohistochemical staining and genetic analysis.

Case presentation

Two Asian patients with TTE without PMDS were subjected to orchiopexy. We performed testicular biopsies during operation and obtained blood samples before the operation. Testicular tissues were stained for c-kit, placental alkaline phosphatase (PLAP), and undifferentiated embryonic cell transcriptio

SUBMITTER: Nagai T 

PROVIDER: S-EPMC7706043 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature