Development of specialized sensory neurons engages a nuclear receptor required for functional plasticity.

ABSTRACT: During development, the nervous system generates neurons that serve highly specialized roles and, accordingly, possess unique functional attributes. The chemosensory BAG neurons of C. elegans are striking exemplars of this. BAGs sense the respiratory gas carbon dioxide (CO₂) and, in a context-dependent manner, switch from mediating avoidance of CO₂ to supporting CO₂ attraction. To determine mechanisms that support the physiology and plasticity of BAG neurons, we used tandem ChIP-seq and cell targeted RNA-seq to identify gene targets of the transcription factor ETS-5, which is required for BAG development. A functional screen of ETS-5 targets revealed that NHR-6, the sole C. elegans NR4A-type nuclear receptor, is required for BAG-mediated avoid

SUBMITTER: Rossillo M 

PROVIDER: S-EPMC7706712 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature