Sequencing identifies multiple early introductions of SARS-CoV-2 to the New York City region.

ABSTRACT: Effective public response to a pandemic relies upon accurate measurement of the extent and dynamics of an outbreak. Viral genome sequencing has emerged as a powerful approach to link seemingly unrelated cases, and large-scale sequencing surveillance can inform on critical epidemiological parameters. Here, we report the analysis of 864 SARS-CoV-2 sequences from cases in the New York City metropolitan area during the COVID-19 outbreak in spring 2020. The majority of cases had no recent travel history or known exposure, and genetically linked cases were spread throughout the region. Comparison to global viral sequences showed that early transmission was most linked to cases from Europe. Our data are consistent with numerous seeds from multiple sources and a prolonged period of unrecognized co

SUBMITTER: Maurano MT 

PROVIDER: S-EPMC7706732 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature