Antipsychotic Dose in Acute Schizophrenia: A Meta-analysis.

ABSTRACT: Little is known regarding optimal antipsychotic doses in the acute phase of schizophrenia. The aim of the present study was to employ the concept of minimum effective dose (MED) in examining efficacy and tolerability within this population. MED was identified for each antipsychotic through a previous systematic review. We then identified double-blind placebo-controlled randomized trials that involved fixed-dose antipsychotic monotherapy in acute schizophrenia and compared the identified MED vs higher doses of the same oral antipsychotic. Studies were selected from a recent meta-analysis examining dose-response relationship of second-generation antipsychotics and haloperidol. We extracted the data on study discontinuation, psychopathology, extrapyramidal symptoms, and treatment-emergent adv

SUBMITTER: Takeuchi H 

PROVIDER: S-EPMC7707077 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature