Cortical Gyrification, Psychotic-Like Experiences, and Cognitive Performance in Nonclinical Subjects.

ABSTRACT:

Background

Psychotic-like experiences (PLE) are present in nonclinical populations, yet their association with brain structural variation, especially markers of early neurodevelopment, is poorly understood. We tested the hypothesis that cortical surface gyrification, a putative marker of early brain development, is associated with PLE in healthy subjects.

Methods

We analyzed gyrification from 3 Tesla MRI scans (using CAT12 software) and PLE (positive, negative, and depressive symptom dimensions derived from the Community Assessment of Psychic Experiences, CAPE) in 103 healthy participants (49 females, mean age 29.13 ± 9.37 years). A subsample of 63 individuals completed tasks from the Wechsler Adult Intelligence Scale and Controlled Oral Word Association Test. Estimated IQ a

SUBMITTER: Evermann U 

PROVIDER: S-EPMC7707080 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature