Comparative efficacy and safety of lactulose plus paraffin vs polyethylene glycol in functional constipation: a randomised clinical study.

ABSTRACT:

Background

Few head-to-head comparisons of the different classes of laxatives have been conducted.

Objective

The objective of this work is to compare the efficacy of lactulose plus paraffin vs polyethylene glycol in the treatment of functional constipation (non-inferiority study).

Methods

This randomised, parallel-group, multicentre phase 4 study recruited patients with functional constipation diagnosed according to Rome III criteria. Patients received lactulose plus paraffin or polyethylene glycol for 28 days. The primary end point was the change from baseline in the Patient Assessment of Constipation-Symptoms (PAC-SYM) score.

Results

A total of 363 patients were randomised to lactulose plus paraffin (n = 179) or polyethylene glycol (n = 184). On

SUBMITTER: Piche T 

PROVIDER: S-EPMC7707874 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature