Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study.

ABSTRACT:

Background

The rising prevalence of type 2 diabetes (T2D) poses a major global challenge. It remains unresolved to what extent transcriptomic signatures of metabolic dysregulation and T2D can be observed in easily accessible tissues such as blood. Additionally, large-scale human studies are required to further our understanding of the putative inflammatory component of insulin resistance and T2D. Here we used transcriptomics data from individuals with (n = 789) and without (n = 2127) T2D from the IMI-DIRECT cohorts to describe the co-expression structure of whole blood that mainly reflects processes and cell types of the immune system, and how it relates to metabolically relevant clinical traits and T2D.

Methods

Clusters of co-expressed genes were identified in the non-diabe

SUBMITTER: Gudmundsdottir V 

PROVIDER: S-EPMC7708171 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature