Whole blood DNA methylation aging markers predict colorectal cancer survival: a prospective cohort study.

ABSTRACT:

Background

Blood DNA methylation-based aging algorithms predict mortality in the general population. We investigated the prognostic value of five established DNA methylation aging algorithms for patients with colorectal cancer (CRC).

Methods

AgeAccelHorvath, AgeAccelHannum, DNAmMRscore, AgeAccelPheno and AgeAccelGrim were constructed using whole blood epi-genomic data from 2206 CRC patients. After a median follow-up of 6.2 years, 1079 deaths were documented, including 596 from CRC. Associations of the aging algorithms with survival outcomes were evaluated using the Cox regression and survival curves. Harrell's C-statistics were computed to investigate predictive performance.

Results

Adjusted hazard ratios (95% confidence intervals) of all-cause mortality for patients

SUBMITTER: Gao X 

PROVIDER: S-EPMC7708179 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature