Differential gene expression analysis reveals pathways important in early post-traumatic osteoarthritis in an equine model.

ABSTRACT:

Background

Post-traumatic osteoarthritis (PTOA) is a common and significant problem in equine athletes. It is a disease of the entire joint, with the synovium thought to be a key player in disease onset and progression due to its role in inflammation. The development of effective tools for early diagnosis and treatment of PTOA remains an elusive goal. Altered gene expression represents the earliest discernable disease-related change, and can provide valuable information about disease pathogenesis and identify potential therapeutic targets. However, there is limited work examining global gene expression changes in early disease. In this study, we quantified gene expression changes in the synovium of osteoarthritis-affected joints using an equine metacarpophalangeal joint (MCPJ) chip

SUBMITTER: McCoy AM 

PROVIDER: S-EPMC7708211 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature