Virulence characterization and comparative genomics of Listeria monocytogenes sequence type 155 strains.

ABSTRACT:

Background

Listeria (L.) monocytogenes strains show a high diversity regarding stress tolerance and virulence potential. Genome studies have mainly focused on specific sequence types (STs) predominantly associated with either food or human listeriosis. This study focused on the prevalent ST155, showing equal distribution among clinical and food isolates. We evaluated the virulence potential of 20 ST155 strains and performed comparative genomic analysis of 130 ST155 strains isolated from food, food processing environments and human listeriosis cases in different countries and years.

Results

The in vitro virulence assays using human intestinal epithelial Caco2 and hepatocytic HEPG2 cells showed an impaired virulence phenotype for six of the 20 selected ST155 strains. Genome an

SUBMITTER: Wagner E 

PROVIDER: S-EPMC7708227 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature