Epidrug Repurposing: Discovering New Faces of Old Acquaintances in Cancer Therapy.

ABSTRACT: Gene mutations are strongly associated with tumor progression and are well known in cancer development. However, recently discovered epigenetic alterations have shown the potential to greatly influence tumoral response to therapy regimens. Such epigenetic alterations have proven to be dynamic, and thus could be restored. Due to their reversible nature, the promising opportunity to improve chemotherapy response using epigenetic therapy has arisen. Beyond helping to understand the biology of the disease, the use of modern clinical epigenetics is being incorporated into the management of the cancer patient. Potential epidrug candidates can be found through a process known as drug repositioning or repurposing, a promising strategy for the discovery of novel potential targets in already approve

SUBMITTER: Montalvo-Casimiro M 

PROVIDER: S-EPMC7708379 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature