A combined cohort analysis of prenatal exposure to phthalate mixtures and childhood asthma.

ABSTRACT:

Background

Previous studies of prenatal phthalate exposure and childhood asthma are inconsistent. These studies typically model phthalates as individual, rather than co-occurring, exposures. We investigated whether prenatal phthalates are associated with childhood wheeze and asthma using a mixtures approach.

Methods

We studied dyads from two prenatal cohorts in the ECHO-PATHWAYS consortium: CANDLE, recruited 2006-2011 and TIDES, recruited 2011-2013. Parents reported child respiratory outcomes at age 4-6 years: ever asthma, current wheeze (symptoms in past 12 months) and current asthma (two affirmative responses from ever asthma, recent asthma-specific medication use, and/or current wheeze). We quantified 11 phthalate metabolites in third trimester urine and estimated associa

SUBMITTER: Adgent MA 

PROVIDER: S-EPMC7708520 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature