High throughput profiling of undifferentiated pleomorphic sarcomas identifies two main subgroups with distinct immune profile, clinical outcome and sensitivity to targeted therapies.

ABSTRACT:

Background

Undifferentiated pleomorphic sarcoma (UPS) is the most frequent, aggressive and less-characterized sarcoma subtype. This study aims to assess UPS molecular characteristics and identify specific therapeutic targets.

Methods

High-throughput technologies encompassing immunohistochemistry, RNA-sequencing, whole exome-sequencing, mass spectrometry, as well as radiomics were used to characterize three independent cohorts of 110, 25 and 41 UPS selected after histological review performed by an expert pathologist. Correlations were made with clinical outcome. Cell lines and xenografts were derived from human samples for functional experiments.

Findings

CD8 positive cell density was independently associated with metastatic behavior and prognosis. RNA-sequencing iden

SUBMITTER: Toulmonde M 

PROVIDER: S-EPMC7708794 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature