Maternal plasma miRNAs as potential biomarkers for detecting risk of small-for-gestational-age births.

ABSTRACT:

Background

Small-for-gestational-age fetuses (SGA) (birthweight <10th centile) are at high risk for stillbirth or long-term adverse outcomes. Here, we investigate the ability of circulating maternal plasma miRNAs to determine the risk of SGA births.

Methods

Maternal plasma samples from 29 women of whom 16 subsequently delivered normally grown babies and 13 delivered SGA (birthweight <5th centile) were selected from a total of 511 women recruited to form a discovery cohort in which expression data for a total of 800 miRNAs was determined using the Nanostring nCounter miRNA assay. Validation by RT-qPCR was performed in an independent cohort.

Findings

Partial least-squares discriminant analysis (PLS-DA) of the Nanostring nCounter miRNA assay initially identified seven mi

SUBMITTER: Kim SH 

PROVIDER: S-EPMC7708817 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature