Cancer risk in individuals with major birth defects: large Nordic population based case-control study among children, adolescents, and adults.

ABSTRACT:

Objective

To examine associations between birth defects and cancer from birth into adulthood.

Design

Population based nested case-control study.

Setting

Nationwide health registries in Denmark, Finland, Norway, and Sweden.

Participants

62 295 cancer cases (0-46 years) and 724 542 frequency matched controls (matched on country and birth year), born between 1967 and 2014.

Main outcome measures

Relative risk of cancer in relation to major birth defects, estimated as odds ratios with 99% confidence intervals from logistic regression models.

Results

Altogether, 3.5% (2160/62 295) of cases and 2.2% (15 826/724 542) of controls were born with major birth defects. The odds ratio of cancer for people with major birth defects compared with those without was

SUBMITTER: Daltveit DS 

PROVIDER: S-EPMC7708828 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature