Active conventional treatment and three different biological treatments in early rheumatoid arthritis: phase IV investigator initiated, randomised, observer blinded clinical trial.

ABSTRACT:

Objective

To evaluate and compare benefits and harms of three biological treatments with different modes of action versus active conventional treatment in patients with early rheumatoid arthritis.

Design

Investigator initiated, randomised, open label, blinded assessor, multiarm, phase IV study.

Setting

Twenty nine rheumatology departments in Sweden, Denmark, Norway, Finland, the Netherlands, and Iceland between 2012 and 2018.

Participants

Patients aged 18 years and older with treatment naive rheumatoid arthritis, symptom duration less than 24 months, moderate to severe disease activity, and rheumatoid factor or anti-citrullinated protein antibody positivity, or increased C reactive protein.

Interventions

Randomised 1:1:1:1, stratified by country, sex, an

SUBMITTER: Hetland ML 

PROVIDER: S-EPMC7708829 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature