Neurons under genetic control: What are the next steps towards the treatment of movement disorders?

ABSTRACT: Since the implementation of deep-brain stimulation as a therapy for movement disorders, there has been little progress in the clinical application of novel alternative treatments. Movement disorders are a group of neurological conditions, which are characterised with impairment of voluntary movement and share similar anatomical loci across the basal ganglia. The focus of the current review is on Parkinson's disease and Huntington's disease as they are the most investigated hypokinetic and hyperkinetic movement disorders, respectively. The last decade has seen enormous advances in the development of laboratory techniques that control neuronal activity. The two major ways to genetically control the neuronal function are: 1) expression of light-sensitive proteins that allow for the optogeneti

SUBMITTER: Tsanov M 

PROVIDER: S-EPMC7708864 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature