Progression of brain functional connectivity and frontal cognitive dysfunction in ALS.

ABSTRACT:

Objective

To investigate the progression of resting-state functional connectivity (rs-FC) changes in patients with amyotrophic lateral sclerosis (ALS) and their relationship with frontal cognitive alterations.

Methods

This is a multicentre, observational and longitudinal study. At baseline and after six months, 25 ALS patients underwent 3D T1-weighted MRI, resting-state functional MRI (rs-fMRI), and the computerized Test of Attentional Performance (TAP). Using independent component analysis, rs-FC changes of brain networks involving connections to frontal lobes and their relationship with baseline cognitive scores and cognitive changes over time were assessed. With a seed-based approach, rs-FC longitudinal changes of the middle frontal gyrus (MFG) were also explored.

Resu

SUBMITTER: Castelnovo V 

PROVIDER: S-EPMC7708866 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature