Effect of diet and intestinal AhR expression on fecal microbiome and metabolomic profiles.

ABSTRACT:

Background

Diet, loss of aryl hydrocarbon receptor (AhR) expression and their modification of the gut microbiota community composition and its metabolites affect the development of colorectal cancer (CRC). However, the concordance between fecal microbiota composition and the fecal metabolome is poorly understood. Mice with specific AhR deletion (AhRKO) in intestinal epithelial cell and their wild-type littermates were fed a low-fat diet or a high-fat diet. Shifts in the fecal microbiome and metabolome associated with diet and loss of AhR expression were assessed. Microbiome and metabolome data were integrated to identify specific microbial taxa that contributed to the observed metabolite shifts.

Results

Our analysis shows that diet has a more pronounced effect on mouse fecal

SUBMITTER: Yang F 

PROVIDER: S-EPMC7708923 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature