Effect of Cannabidiol and Δ9-Tetrahydrocannabinol on Driving Performance: A Randomized Clinical Trial.

ABSTRACT:

Importance

Cannabis use has been associated with increased crash risk, but the effect of cannabidiol (CBD) on driving is unclear.

Objective

To determine the driving impairment caused by vaporized cannabis containing Δ9-tetrahydrocannabinol (THC) and CBD.

Design, setting, and participants

A double-blind, within-participants, randomized clinical trial was conducted at the Faculty of Psychology and Neuroscience at Maastricht University in the Netherlands between May 20, 2019, and March 27, 2020. Participants (N = 26) were healthy occasional users of cannabis.

Interventions

Participants vaporized THC-dominant, CBD-dominant, THC/CBD-equivalent, and placebo cannabis. THC and CBD doses were 13.75 mg. Order of conditions was randomized and balanced.

Main outcomes an

SUBMITTER: Arkell TR 

PROVIDER: S-EPMC7709000 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature