Association between Serum Vitamin B12 and Global DNA Methylation in Colorectal Cancer Patients.

ABSTRACT: Vitamin B12 has been widely related to methionine metabolism, which is an essential component for biological methylation reactions, including DNA methylation. However, the relationship between vitamin B12 and DNA methylation is still controversial. In addition, there is increasing evidence for the association between vitamin B12 and the risk of colorectal cancer (CRC), although results of this association need to be assessed with caution. For this purpose, we hypothesized that serum vitamin B12 could be associated with global DNA methylation in the CRC context. To test this hypothesis, we studied the association between global DNA methylation through long interspersed nuclear element-1 (LINE1) in CRC patients under the 25th percentile of serum vitamin B12. We found that the high vitamin B1

SUBMITTER: Boughanem H 

PROVIDER: S-EPMC7709022 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature