MicroRNAs and Mammarenaviruses: Modulating Cellular Metabolism.

ABSTRACT: Mammarenaviruses are a diverse genus of emerging viruses that include several causative agents of severe viral hemorrhagic fevers with high mortality in humans. Although these viruses share many similarities, important differences with regard to pathogenicity, type of immune response, and molecular mechanisms during virus infection are different between and within New World and Old World viral infections. Viruses rely exclusively on the host cellular machinery to translate their genome, and therefore to replicate and propagate. miRNAs are the crucial factor in diverse biological processes such as antiviral defense, oncogenesis, and cell development. The viral infection can exert a profound impact on the cellular miRNA expression profile, and numerous RNA viruses have been reported to inter

SUBMITTER: Fernandes J 

PROVIDER: S-EPMC7709035 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature