Ontology highlight
ABSTRACT:
SUBMITTER: Liu R
PROVIDER: S-EPMC7709126 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Liu Rena R Oldham Robert J RJ Teal Emma E Beers Stephen A SA Cragg Mark S MS
Antibodies (Basel, Switzerland) 20201117 4
The majority of monoclonal antibody (mAb) therapeutics possess the ability to engage innate immune effectors through interactions mediated by their fragment crystallizable (Fc) domain. By delivering Fc-Fc gamma receptor (FcγR) and Fc-C1q interactions, mAb are able to link exquisite specificity to powerful cellular and complement-mediated effector functions. Fc interactions can also facilitate enhanced target clustering to evoke potent receptor signaling. These observations have driven decades-lo ...[more]