Preconception Alcohol Exposure Increases the Susceptibility to Diabetes in the Offspring.

ABSTRACT: Heavy alcohol drinking alters glucose metabolism, but the inheritability of this effect of alcohol is not well understood. We used an animal model of preconception alcohol exposure in which adult female rats were given free access to 6.7% alcohol in a liquid diet and water for about 4 weeks, went without alcohol for 3 weeks, and then were bred to generate male and female offspring. Control animals were either ad lib-fed rat chow or pair-fed an isocaloric liquid diet during the time of alcohol-feeding in the experimental animals. Our results show that the female rats fed with alcohol in the liquid diet, but not with the isocaloric liquid diet, prior to conception had an altered stress gene network involving glucose metabolism in oocytes when compared with those in ad lib-fed chow diet contr

SUBMITTER: Al-Yasari A 

PROVIDER: S-EPMC7709217 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature