MiR-29c-3p regulates proliferation and migration in ovarian cancer by targeting KIF4A.

ABSTRACT:

Background

Increasing evidence suggested that microRNA and kinesin superfamily proteins play an essential role in ovarian cancer. The association between KIF4A and ovarian cancer (OC) was investigated in this study.

Methods

We performed bioinformatics analysis in the GEO database to screen out the differentially expressed miRNAs (DEmiRNAs) associated with ovarian cancer prognosis. Upstream targeting prediction for KIF4A was acquired by using the mirDIP database. The potential regulatory factor miR-29c-3p for KIF4A was obtained from the intersection of the above all miRNAs. The prognosis of KIF4A and target-miRNA in OC was obtained in the subsequent analysis. qRT-PCR and Western blot detected KIF4A expression level in IOSE80 (human normal ovarian epithelial cell line). In the

SUBMITTER: Feng S 

PROVIDER: S-EPMC7709319 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature