Role of circulating fibrocytes in the diagnosis of acute appendicitis.

ABSTRACT:

Background

Improved diagnostic biomarkers are required for acute appendicitis. The circulating fibrocyte percentage (CFP) is increased in inflammatory states, but has not been studied in acute appendicitis. This study aimed to determine CFP in acute appendicitis and compare diagnostic accuracy with standard serological biomarkers.

Methods

A prospective cohort study was carried out between June 2015 and February 2016 at University Hospital Limerick. The CFP was determined by dual-staining peripheral venous samples for CD45 and collagen I using fluorescence-activated cell sorting, and correlated with histopathological diagnoses. The accuracy of CFP in determining histological acute appendicitis was characterized and compared with the white cell count, C-reactive protein concen

SUBMITTER: Zarog MA 

PROVIDER: S-EPMC7709380 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature