Comparison of factor XII levels in gestational diabetes, fetal macrosomia, and healthy pregnancies.

ABSTRACT:

Background

If not detected and treated, gestational diabetes mellitus (GDM) can cause serious pregnancy complications such as macrosomia, preeclampsia, and fetal/neonatal mortality. Many studies have examined underlying contributing factors for GDM, including hypercoagulation. Factor XII (FXII) is a coagulation factor that increases throughout normal pregnancies, and we evaluated the relationship of GDM with FXII, FXIIa (activated FXII), and other coagulation parameter levels. GDM and macrosomia are closely related, but it is not known whether FXII could be an independent causal factor for macrosomia.

Methods

In this prospective study, blood samples were taken from 69 pregnant women at the time of term delivery to determine levels of FXII, FXIIa, and other coagulation parame

SUBMITTER: Ozbasli E 

PROVIDER: S-EPMC7709445 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature