Histone deacetylase 6 inhibition in urothelial cancer as a potential new strategy for cancer treatment.

ABSTRACT: Histone deacetylases (HDACs) are enzymes that remove acetyl groups from histones and have attracted attention as potential targets for cancer therapy. Several small molecule inhibitors have been developed to target HDACs; however, clinical trials of pan-HDAC inhibitors have found these types of inhibitors to be inefficient and to be relatively highly toxic. In the present study, the role of one HDAC isozyme, HDAC6, in urothelial cancer was investigated. Protein expression levels and subcellular localization of HDAC6 was identified in surgically resected bladder tumors using immunohistochemistry. The antitumor effects of 12 small molecule HDAC6 inhibitors were also examined in vitro using cultured urothelial cancer cells. The HDAC6 inhibitors decreased cell viability, with IC_50<

SUBMITTER: Kuroki H 

PROVIDER: S-EPMC7709567 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature