ACE2 and TMPRSS2 polymorphisms in various diseases with special reference to its impact on COVID-19 disease.

ABSTRACT:

Background

A carboxypeptidase protein called ACE2 is found in many organs. ACE2 protein can play a pivotal role to regulate the pathological changes of several diseases including COVID-19. TMPRSS2 gene is expressed in many human tissues and plays a critical role in spreading the infection of the viruses including coronavirus and progression of prostate cancer, and hence could be used as a potential drug target. There are limited reports on occurrence of genetic polymorphism of ACE2 and TMPRSS2 in general population, expressions in pathological conditions, and its impact on COVID-19 disease. Hence we comprehended the occurrence of ACE2, TMPRSS2 polymorphism in general population, expression in various diseases and its impact on COVID-19 disease.

Method

We utilized multiple da

SUBMITTER: Singh H 

PROVIDER: S-EPMC7709597 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature