Optimization by Central Composite Experimental Design of the Synthesis of Physically Crosslinked Chitosan Spheres.

ABSTRACT: Chitosan (CS) has special properties such as biocompatibility, biodegradability, antibacterial, and biological activity which make this material is currently studied in various applications, including tissue engineering. There are different methods to modify the morphology of CS. Most use chemical crosslinking agents, however, those methods have disadvantages such as low polymer degradability and unwanted side effects. The objective of this research was to obtain CS spheres through the physical crosslinking of commercial CS without using crosslinking agents through a simple coacervation method. A central composite experimental design was used to optimize the synthesis of the CS spheres and by the response surface methodology it was possible to obtain CS spheres with the smallest diameter a

SUBMITTER: Zamora Lagos SI 

PROVIDER: S-EPMC7709620 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature