In Silico Structural and Functional Characterization of HtrA Proteins of Leptospira spp.: Possible Implications in Pathogenesis.

ABSTRACT: Leptospirosis is a zoonosis caused by the pathogenic bacteria of the genus Leptospira. The identification of conserved outer membrane proteins among pathogenic strains is a major research target in elucidating mechanisms of pathogenicity. Surface-exposed proteins are most probably the ones involved in the interaction of leptospires with the environment. Some spirochetes use outer membrane proteases as a way to penetrate host tissues. HtrA is a family of proteins found in various cell types, from prokaryotes to primates. They are a set of proteases usually composed of a serine protease and PDZ domains, and they are generally transported to the periplasm. Here, we identified four genes-annotated as HtrA, LIC11111, LIC20143, LIC20144 and LIC11037-and another one annotated as a serine protease

SUBMITTER: Daroz BB 

PROVIDER: S-EPMC7709667 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature