Cytokine Panels and Pediatric Acute Respiratory Distress Syndrome: A Translational Investigation.

ABSTRACT:

Objectives

To identify and compare serum and lower respiratory tract fluid biomarkers of lung injury using well-characterized mouse models of lung injury. To explore the relationship between these preclinical biomarkers and clinical outcomes in a discovery cohort of pediatric patients with acute respiratory failure from pneumonia.

Design

Prospective, observational cohort study.

Setting

A basic science laboratory and the PICU of a tertiary-care children's hospital.

Patients

PICU patients intubated for respiratory failure from a suspected respiratory infection.

Interventions

Prospective enrollment and collection of lower respiratory tract fluid samples.

Measurements and main results

C57BL6/J mice were intranasally inoculated with escalating doses of

SUBMITTER: McKeone DJ 

PROVIDER: S-EPMC7709920 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature