Potency of gastrointestinal colonization and virulence of Candida auris in a murine endogenous candidiasis.

ABSTRACT:

Background

Candida auris infections have recently emerged worldwide, and this species is highly capable of colonization and is associated with high levels of mortality. However, strain-dependent differences in colonization capabilities and virulence have not yet been reported.

Objectives

In the present study, we aimed to clarify the differences between clinically isolated invasive and non-invasive strains of C. auris.

Methods

We evaluated colonization, dissemination, and survival rates in wild C57BL/6J mice inoculated with invasive or non-invasive strains of C. auris under cortisone acetate immunosuppression, comparing with those of Candida albicans and Candida glabrata infections. We also evaluated the potency of biofilm formation.

Results

Stool fungal burdens

SUBMITTER: Abe M 

PROVIDER: S-EPMC7710084 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature