Maternal exposure to sulfonamides and adverse pregnancy outcomes: A systematic review and meta-analysis.

ABSTRACT:

Background

Sulfonamides are widely used to treat infectious diseases during pregnancy. However, the safety of maternal exposure to sulfonamides is controversial. This study aims to systematically review the available studies and examine the effect of maternal sulfonamides use on adverse pregnancy outcomes.

Methods

We searched PubMed, Science Direct, Web of Science, ClinicalTrials.gov, CNKI and Wanfang Database (in Chinese). The meta-analysis used random effects model or fixed effects model to obtain the total odds ratio (OR) for each outcome through Stata11.0 software. Study on the relationship between sulfonamide exposure during pregnancy and adverse pregnancy outcomes. The study design covered randomized controlled trials, cohort studies and case-control studies. The study

SUBMITTER: Li P 

PROVIDER: S-EPMC7710089 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature