The proteomic landscape of small urinary extracellular vesicles during kidney transplantation.

ABSTRACT: Kidney transplantation is the preferred renal replacement therapy available. Yet, long-term transplant survival is unsatisfactory, partially due to insufficient possibilities of longitudinal monitoring and understanding of the biological processes after transplantation. Small urinary extracellular vesicles (suEVs) - as a non-invasive source of information - were collected from 22 living donors and recipients. Unbiased proteomic analysis revealed temporal patterns of suEV protein signature and cellular processes involved in both early response and longer-term graft adaptation. Complement activation was among the most dynamically regulated components. This unique atlas of the suEV proteome is provided through an online repository allowing dynamic interrogation by the user. Additionally, a co

SUBMITTER: Braun F 

PROVIDER: S-EPMC7710132 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature