Global Proteome and Phosphoproteome Characterization of Sepsis-induced Kidney Injury.

ABSTRACT: Sepsis-induced acute kidney injury (S-AKI) is the most common complication in hospitalized and critically ill patients, highlighted by a rapid decline of kidney function occurring a few hours or days after sepsis onset. Systemic inflammation elicited by microbial infections is believed to lead to kidney damage under immunocompromised conditions. However, although AKI has been recognized as a disease with long-term sequelae, partly because of the associated higher risk of chronic kidney disease (CKD), the understanding of kidney pathophysiology at the molecular level and the global view of dynamic regulations in situ after S-AKI, including the transition to CKD, remains limited. Existing studies of S-AKI mainly focus on deriving sepsis biomarkers from body fluids. In the present stud

SUBMITTER: Lin YH 

PROVIDER: S-EPMC7710145 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature