Idem: An R Package for Inferences in Clinical Trials with Death and Missingness.

ABSTRACT: In randomized controlled trials of seriously ill patients, death is common and often defined as the primary endpoint. Increasingly, non-mortality outcomes such as functional outcomes are co-primary or secondary endpoints. Functional outcomes are not defined for patients who die, referred to as "truncation due to death", and among survivors, functional outcomes are often unobserved due to missed clinic visits or loss to follow-up. It is well known that if the functional outcomes "truncated due to death" or missing are handled inappropriately, treatment effect estimation can be biased. In this paper, we describe the package idem that implements a procedure for comparing treatments that is based on a composite endpoint of mortality and the functional outcome among survivors. Among surv

SUBMITTER: Wang C 

PROVIDER: S-EPMC7710152 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature