Bioinformatic analysis of the pathogenic mechanism of talaromyces marneffei infection.

ABSTRACT:

Background

Talaromyces marneffei (T marneffei), known as a significant pathogen in patients with AIDS in Southeast Asia, is a dimorphic fungus, which can cause deadly systematic infection in immunocompromised hosts. What is more, the dimorphic phase transition has been reported as a conspicuous process linked with virulence. Interestingly, the yeast form was found in infected individuals, representing the pathogenic phase. However, few researches were found to study the mechanism of dimorphic transition. Thus, a diverse insight into the dimorphic switch mechanism, is urgently needed and we are the first one to research the mechanism of dimorphism.

Methods

Firstly, we investigated the microarray of T. marneffei in the Gene Expression Omnibus database (GEO) for differentially

SUBMITTER: Cen J 

PROVIDER: S-EPMC7710178 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature