Correlation between CYP11B2 polymorphism and the risk of preeclampsia.

ABSTRACT:

Background

Many studies have evaluated the association between aldosterone synthase (CYP11B2) C-344T polymorphism and preeclampsia (PE) susceptibility, however, the results from different studies are inconsistent.

Objective

The study aimed to derive a more precise estimation of this association.

Methods

We searched PubMed, Embase, Chinese National Knowledge Infrastructure, China Biological Medicine, and Wanfang Database. The association was evaluated by calculating the odds ratios (ORs) with the corresponding 95% confidence intervals (CIs).

Results

Seven case-control studies with a total of 720 cases and 766 controls were eligible to be included in this meta-analysis. Overall, there was no significant association between CYP11B2 C-344T polymorphism and PE (for

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7710233 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature