Identification of afzelin potential targets in inhibiting triple-negative breast cancer cell migration using reverse docking.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) tends to be aggressive and metastatic, characteristics attributable to its cellular migration capabilities. Afzelin is a chemical compound with anti-metastatic potentials. This study aimed to predict proteins involved in TNBC cell migration which could be inhibited by afzelin.

Methods

The protein database was constructed from the Kyoto Encyclopedia of Genes and Genomes pathways collection which related to cell motility, then screened for druggability using SuperTarget and Therapeutic Target Database. The involvement of druggable proteins in the TNBC metastasis process was investigated through existing publications in The National Center for Biotechnology Information PubMed database. Inhibitory potential of afzelin toward target

SUBMITTER: Rachmi E 

PROVIDER: S-EPMC7710241 | biostudies-literature | 2020 Nov-Dec

REPOSITORIES: biostudies-literature